Methadone for Depression

Overview
Methadone is approved by the U.S. Food and Drug Administration (FDA) for the treatment of opioid use disorder (OUD) in adults. It is used to reduce withdrawal symptoms and cravings in people who are dependent on opioids such as heroin or prescription painkillers. Methadone must be dispensed through certified opioid treatment programs (OTPs) that follow strict federal regulations. These programs include regular medical supervision, counseling, and drug testing to support long-term recovery. Methadone is also known by its generic name, methadone.

Methadone is an opioid agonist. It works by activating the same brain receptors as other opioids, helping to prevent withdrawal symptoms and reduce cravings without producing the same euphoric effects. This allows individuals to stabilize their health and engage in recovery while reducing the risk of relapse.

How do I take it?
Prescribing information states that methadone is taken once daily by mouth as part of a structured opioid treatment program. It is available as a liquid, dispersible tablet, or standard tablet. 

Methadone is typically administered at the treatment facility under supervision, especially during the early phases of treatment. A prescribing doctor may adjust the dosing schedule over time depending on how a person responds. 

Methadone should be taken exactly as prescribed by a healthcare provider.

Side effects
Common side effects of methadone include dizziness, drowsiness, nausea, vomiting, constipation, increased sweating, and sedation. Some people may also experience dry mouth, mood changes, or difficulty sleeping.

Rare but serious side effects may include life-threatening breathing problems, especially when starting treatment or after a dose increase. Methadone can also cause heart rhythm problems such as QT prolongation, which may result in fainting or sudden death. 

Other serious risks include serotonin syndrome (a potentially dangerous reaction involving confusion, fever, or muscle stiffness), adrenal insufficiency (hormone imbalance), and severe low blood pressure. 

Methadone may cause withdrawal symptoms in newborns if taken during pregnancy. Taking methadone with alcohol, benzodiazepines, or other sedating drugs increases the risk of overdose and death. 

For more information about this treatment, visit:

Methadone — MedlinePlus

Methadone — Drugs.com