Years ago, my family doctor admitted that my depression was outside of his proficiency. I have a psychiatrist now, and I've been on up to 3 different antidepressants at a time. We adjust meds and doses to see what works, which changes over time. He calls it a cocktail.

I am on Saphris (10 mg) at bedtime and Lamictal (a mood stabilizer). I encourage you to not give up. I was diagnosed with recurrent clinical depression back in the late 1980s...over the years had different doctors who tried so many antideppressant and/or combinations there of. The drugs seemed to work for awhile, then guit and we'd try yet again other ones. If trying different drugs and not finding one (s) that help, ask to be reevaluated to see if your diagnosis should be changed. It could be a life saver. In my case the depression diagnosis stuck up until 2017 because my doctors only saw depressive mood. If I was in a good mood, they didn't consider that I might be bipolar. I came in to the clinic one day without an appt in crisis. My mood were all over the gamut. The only doctor they had available was 2 hours away in charleston and had to be seen by teleconference. When I described the fluctuating moods, she zeroed in on the"happy" feeling and asked probing questions like what does it feel like, does it come on slowly or like turning on a light switch, what do you do when happy (talk fast and too much, any reckless behavior like overspending, etc). She then informed me I was bipolar and the drugs for clinical depression does not work for bipolar depression. I am NOT saying your diagnosis is wrong, but one possibility is to describe all the symptoms, behaviors etc that have happened over the history of your illness. It might give the doctor more info with which to work from. Good luck...I will keep you in my prayers. I know how frustrated i got over the years.

Yes I take two medications for my bipolar one is Carbamazepine and Citalopram and they work for me with not trouble. Goods Luck in finding the right medications that work for you.

Yes I've been on 4 meds at the same time, this did help for a period of time and now on 2 meds and diazepam, don't be scared about ur meds, if it helps that's all that matters x

My Dr had me on 450mg Welbutrin and started me on Viibryd (sample pack) after 4 weeks I started having suicidal thoughts. Unfortunately meds have never worked (22 years of trying different meds) God bless ♡